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St. John's Wort as a Treatment for Depression

Chevallier, A. (2000, January 18). St. John's Wort. Retrieved February 5, 2002 from the World Wide



I found this site using the Librarians' Index Directory. It discusses Ireland's new designation for this herb as a "prescription only" drug, because they are afraid people will use this herb rather than seek medical help for depression.

Gaster B., & Holroyd, J. (2000, January 24). St John's wort for depression: a systematic review.

      Archives of Internal Medicine, 152. Retrieved November 15, 2001, from EBSCOhost database

      (MasterFile Premier on-line) on the World Wide Web:


A review of all the double-blind, randomized trials on the use of St. John's wort for depression finds that it is more effective than a placebo, but less effective than prescription drugs. However, there are very slight side effects, unlike the prescription tricyclic antidepressants. St John's wort is currently unregulated, but the Food and Drug Administration is reviewing plans to tighten its regulatory oversight.

Hurley, J. (1995). The Good Herb. New York: William Morrow & Co.


This is basically a cookbook. Discusses the use of St John's Wort to rub on cuts, scratches and minor burns, or onto stiff joints for relief from arthritis. For depression, a tea is made by steeping a tablespoon of the fresh leaves and flowers in a cup of hot water for 4 minutes. Contains hypericin, a monoamine oxidase (MAO) inhibitor.

St. John's Wort. (1999, March 5). Retrieved February 5, 2001 from the World Wide Web:


This is an information article, posted by a company that sells vitamins and herbal supplements. Includes a page of side effects, which covers MAOI-like reactions to foods like red wine, cheeses, and sausage. Gives a short history of the uses of St. John's Wort as a nerve tonic and mild mood elevator for 2400 years. I found this article using the search engine, HotBot.